ea0038p7 | Bone | SFEBES2015
Houston Dean
, Myers Katherine
, MacRae Vicky
, Millan Jose Luis
, Staines Katherine
, Farquharson Colin
Intermittent PTH therapy is currently the only anabolic therapy for osteoporosis. As the mineralisation of the extracellular matrix of bone is essential for normal function it is vital that the effects of PTH on key regulators of mineralisation are uncovered. Ablation of Alpl, Phospho1 or Smpd3 results in skeletal hypomineralisation and as such this study examined the effects of bovine (b)PTH 134 on their expression. MC3T3 (clone-14) osteoblast-like cells display tempora...